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Mercuri, Giorgio Bernardi, and Thomas Knöpfel. However, much of the inhibitory input from both the CIC and the LL appears to be mediated by interneuronal connections. These experiments have shown that the CIC provides a major glutamatergic and GABAergic input to most ICC neurons. The CIC provided a strong inhibitory input that was almost exclusively GABAergic, whereas the LL inhibition often included a glycinergic component.
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A minority of neurons had synaptic currents that were unaffected by glutamate receptor antagonists, but it was more common for CIC-evoked currents to be unaffected (38%) rather than LL-evoked currents (22%). In addition, this treatment reduced outward synaptic currents at a holding potential of −20 mV, indicating that inhibitory interneuronal input was often activated by LL or CIC afferents. The synaptic currents were typically complex waveforms, and ionotropic glutamate receptor antagonists reduced inward currents at a holding potential of −80 mV in the majority of neurons. In voltage clamp, 79% of ICC neurons displayed synaptic currents after stimulation of each pathway. The depolarization was abolished by AP-5 + CNQX, and the remaining inhibitory potential displayed either bicuculline or strychnine sensitivity.
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In current clamp, LL stimulation typically produced a short latency depolarization followed by a longer duration hyperpolarization. Excitatory and inhibitory synaptic responses were characterized by sequentially exposing the slice to ionotropic glutamate receptor antagonists, a γ-aminobutryic acid type A receptor antagonist (bicuculline), and a glycine receptor antagonist (strychnine). Frontal midbrain slices were obtained from postnatal day (P) 9–P19 gerbils, and whole cell recordings were made under current- ( n = 22) or voltage-clamp ( n = 52) conditions. To evaluate the contribution made to gerbil ICC neuron physiology by two major afferent pathways, we examined the synaptic responses evoked by direct stimulation of the commissure of the inferior colliculus (CIC) and the ipsilateral lateral lemniscus (LL). The central nucleus of the inferior colliculus (ICC) receives direct inputs, bilaterally, from all auditory brain stem nuclear groups. Commissural and lemniscal synaptic input to the gerbil inferior colliculus.